Continuous-flow synthesis of highly functionalized imidazo-oxadiazoles facilitated by microfluidic extraction
نویسندگان
چکیده
A versatile continuous-flow synthesis of highly functionalized 1,2,4-oxadiazoles starting from carboxylic acids is reported. This process was applied to the multistep synthesis of imidazo[1,2-a]pyridin-2-yl-1,2,4-oxadiazoles, using a three reactor, multistep continuous-flow system without isolation of intermediates. This continuous-flow method was successfully combined with a single-step liquid-liquid microextraction unit to remove high boiling point polar solvents and impurities and provides the target compounds in high purity with excellent overall yields.
منابع مشابه
A New synthesis of functionalized imidazo[2,1-b][1,3]thiazines with thiohydantoins, isocyanides and dialkyl acetylenedicarboxylates
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